Brain Amyloid-Beta Fragment Signatures in Pathological Ageing and Alzheimer's Disease by Hybrid Immunoprecipitation Mass Spectrometry.

Conclusion: Senile plaques in AD may have an Aβ fragment composition distinct from PA with more N-terminally and pyroglutamate-modified Aβ peptides that may be linked to neurotoxicity. © 2015 S. Karger AG, Basel.
PMID: 25591542 [PubMed - as supplied by publisher]

Source: Neuro-Degenerative Diseases - January 13, 2015 Category: Neurology Authors: Portelius E, Lashley T, Westerlund A, Persson R, Fox NC, Blennow K, Revesz T, Zetterberg H Tags: Neurodegener Dis Source Type: research