MiR155 modulates vascular calcification by regulating Akt-FOXO3a signalling and apoptosis in vascular smooth muscle cells.

In conclusion, miR155 deficiency attenuates vascular calcification by increasing Akt phosphorylation and FOXO3a degradation, and thus reducing VSMC apoptosis induced by calcification medium.
PMID: 33210462 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - November 18, 2020 Category: Molecular Biology Authors: Li Y, Sun W, Saaoud F, Wang Y, Wang Q, Hodge J, Hui Y, Yin S, Lessner SM, Kong X, Fan D Tags: J Cell Mol Med Source Type: research