Progress in research into the role of abnormal glycosylation modification in tumor immunity.

Progress in research into the role of abnormal glycosylation modification in tumor immunity.
Immunol Lett. 2020 Nov 10;:
Authors: Liu HM, Ma LL, Cao B, Lin JZ, Han L, Li CY, Xu RC, Zhang DK
Abstract
In abnormal glycosylation, molecules of glucose or other carbohydrates in living organisms are inappropriately attached to proteins, which causes protein denaturation. Abnormal glycosylation modification is known to directly or indirectly affect the tumor escape process, but very few studies have been performed on whether protein glycosylation changes the structure and function of immune cells and immune molecules and thereby regulates the occurrence and development of tumor escape. Therefore, this article summarizes the effect of the immune system on tumor escape in association with the abnormal glycosylation process from an immunological perspective.
PMID: 33186635 [PubMed - as supplied by publisher]

Source: Immunology Letters - November 10, 2020 Category: Allergy & Immunology Authors: Liu HM, Ma LL, Cao B, Lin JZ, Han L, Li CY, Xu RC, Zhang DK Tags: Immunol Lett Source Type: research