Cellular compartments challenged by membrane photo-oxidation.

Cellular compartments challenged by membrane photo-oxidation. Arch Biochem Biophys. 2020 Nov 04;:108665 Authors: Tsubone TM, Martins WK, Franco MSF, Silva MN, Itri R, Baptista MS Abstract The lipid composition of membranes impacts directly on the structure and function of the cytoplasmic as well as organelle membranes. Depending on the type of membrane, specific lipids are required to accommodate, intercalate, or pack membrane proteins to the proper functioning of the cells/organelles. Rather than being only a physical barrier that separates the inner from the outer spaces, membranes are responsible for many biochemical events such as cell-to-cell communication, protein-lipid interaction, intracellular signaling, and energy storage. Photochemical reactions occur naturally in many biological membranes and are responsible for diverse processes such as photosynthesis and vision/phototaxis. However, exposition to light in the presence of absorbing molecules produces excited states and other oxidant species that may cause cell aging/death, mutations and many diseases including cancer. At the same time, targeting key compartments of diseased cells can be a promising strategy to treat many diseases in a clinical procedure called Photodynamic Therapy. Here we analyze the relationships between membrane alterations induced by photo-oxidation and the biochemical responses in mammalian cells. We specifically address the impact of photosensitizat...
Source: Archives of Biochemistry and Biophysics - Category: Biochemistry Authors: Tags: Arch Biochem Biophys Source Type: research