Solubility determination and solution thermodynamics of olmesartan medoxomil in (PEG-400 + water) cosolvent mixtures.

Solubility determination and solution thermodynamics of olmesartan medoxomil in (PEG-400 + water) cosolvent mixtures. Drug Dev Ind Pharm. 2020 Nov 05;:1-28 Authors: Al-Shdefat R Abstract The solubility and solution thermodynamic properties of a weakly water-soluble compound olmesartan medoxomil (OLM) in binary "polyethylene glycol (PEG-400) + water" cosolvent compositions were determined. The "mole fraction solubility (x e)" of OLM in binary "PEG-400 + water" cosolvent compositions and pure solvents (PEG-400 and water) was determined at "T = 295.15-330.15 K" and "p = 0.1 MPa". The Hansen solubility parameter (HSP) of OLM, pure PEG-400, pure water and binary "PEG-400 + water" cosolvent compositions free of OLM were also predicted. The obtained x e values of OLM were correlated using "van't Hoff, modified Apelblat, Yalkowsky-Roseman, Jouyban-Acree and Jouyban-Acree-van't Hoff" computational models with the error values of <4.0%. The maximum and minimum x e value of OLM was predicted in neat PEG-400 (1.15 x 10-2 at T = 330.15 K) and neat water (1.90 x 10-7 at T = 295.15 K), respectively. The OLM HSP was predicted to be more close with that of neat PEG-400. The x e value of OLM was found increased significantly with increase in temperature and PEG-400 mass fraction in all "PEG-400 + water" cosolvent compositions including neat PEG-400 and neat water. An "apparent thermodynamic analysis" studies presented an "endother...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research