Insights into Peptide Mediated Antibiofilm Treatment in Chronic Wound; A Bench to Bedside Approach.

Insights into Peptide Mediated Antibiofilm Treatment in Chronic Wound; A Bench to Bedside Approach. Curr Protein Pept Sci. 2020 Nov 02;: Authors: Radhakrishnan MP, Suryaletha K, Shankar A, Savithri AV, George S, Thomas S Abstract Chronic wound biofilm infections are a threat to the population with respect to morbidity and mortality. Presence of multidrug resistant bacterial pathogens in chronic wound renders the action of antibiotics and antibiofilm agents difficult. Therefore an alternative therapy is essential for reducing bacterial biofilm burden. In this scenario, the peptide based antibiofilm therapy for chronic wound biofilm management seeks more attention. Synthetic peptide with a broad range of antibiofilm activity against preformed and established biofilms, ability to kill multispecies bacteria within biofilms and combinatorial activity with other antimicrobial agents give significant insights. In this review we portray the possibilities and difficulties of peptide mediated treatment in chronic wounds biofilm management and how it can be clinically translated into a product. PMID: 33143623 [PubMed - as supplied by publisher]
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Tags: Curr Protein Pept Sci Source Type: research