Smoking regular and low-nicotine cigarettes results in comparable levels of volatile organic compounds in blood and exhaled breath

In this study VOCs levels in headspace of blood and exhaled breath, in the mainstream smoke
of three types of cigarettes of one brand varying in declared tar, nicotine and carbon monoxide
(TNCO) yields are investigated. The objective was to identify whether VOC levels correlate with TNCO
yields of cigarettes smoked according to ISO 3308. Our data show that smoking regular and low-TNCO
cigarettes result in comparable levels of VOCs in blood and exhaled breath. Hence, declared
TNCO-yields as determined with the ISO 3308 machine smoking protocol are irrelevant for predicting
VOC exposure upon human smoking. Venous blood and exhaled breath were sampled from 12 male
volunteers directly before and 10 min after smoking cigarettes on 3 d (day 1 Marlboro Red (regular),
day 2 Marlboro Prime (highly ventilated, low-TNCO), day 3 Marlboro Prime with blocked filter
ventilation (t...

Source: Journal of Breath Research - November 5, 2020 Category: Respiratory Medicine Authors: Charlotte G G M Pauwels, Kim F H Hintzen, Reinskje Talhout, Hans W J M Cremers, Jeroen L A Pennings, Agnieszka Smolinska, Antoon Opperhuizen, Frederik J Van Schooten and Agnes W Boots Source Type: research