The birth, decline, and contemporary re-emergence of endovascular brachytherapy for prevention of in-stent restenosis

Despite the advent of drug-eluting stents and dual antiplatelet therapy in the interventional management of cardiovascular disease, restenosis rates remain high with significant sequelae. Endovascular brachytherapy —popular in the 1990s and early 2000s—has recently resurfaced as a cost-effective treatment option. In this work, we outline the history of endovascular brachytherapy starting with its earliest promise in the 1990s. We discuss the development of drug-eluting stents and dual antiplatelet strategi es and their impact on the perceived benefit of endovascular brachytherapy.

Source: Brachytherapy - October 29, 2020 Category: Cancer & Oncology Authors: Mohamed H. Khattab, Alexander D. Sherry, Colin M. Barker Source Type: research