Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma.

CONCLUSIONS: Proton vs X-ray led to the transcriptional deregulation of a specific subset of genes that is functionally in line with diminished protein translation, UPR activation and increased oxidative stress. This study demonstrates that radiation types trigger distinct molecular responses in lymphoma cells and identifies PPARgamma inhibition as a potential strategy for sensitization of lymphoma to PT.
PMID: 33096164 [PubMed - as supplied by publisher]

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 20, 2020 Category: Radiology Authors: Sertorio M, Nowrouzi A, Akbarpour M, Chetal K, Salomonis N, Brons S, Mascia A, Ionascu D, Shelby McCauley, Kupneski T, Köthe A, Debus J, Perentesis JP, Abdollahi A, Zheng Y, Wells SI Tags: Radiother Oncol Source Type: research