The Performance of an Artificial Neural Network Model in Predicting the Early Distribution Kinetics of Propofol in Morbidly Obese and Lean Subjects.
CONCLUSIONS: A recirculatory model and gated recurrent unit artificial neural network that incorporated ensemble learning both had similar performance and were both superior to a compartmental model in describing our high-resolution pharmacokinetic data of propofol. The potential of neural networks in pharmacokinetic modeling is encouraging but may be limited by the amount of training data available for these models.
PMID: 33079873 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Ingrande J, Gabriel RA, McAuley J, Krasinska K, Chien A, Lemmens HJM Tags: Anesth Analg Source Type: research
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