UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation

Radioresistance is the major obstacle in radiation therapy (RT) for hepatocellular carcinoma (HCC). Dysregulation of DNA damage response (DDR), which includes DNA repair and cell cycle checkpoints activation, ...

Source: Journal of Experimental and Clinical Cancer Research - October 21, 2020 Category: Cancer & Oncology Authors: Jingyuan Sun, Zhenru Zhu, Wenwen Li, Mengying Shen, Chuanhui Cao, Qingcan Sun, Zeqin Guo, Li Liu and Dehua Wu Tags: Research Source Type: research