The effects of treatments with multistrain probiotics on serum aminotransferases, AST-ALT ratio, body weight and survivability scores of rats experimentally infected with Trypanosoma brucei

AbstractProbiotics can modulate gut-liver axis. Effects of administration of multistrain probiotics (MP) on liver damage and overall health of trypanosomic rats were investigated. Thirty male rats randomly assigned to five groups A –E (n = 6), and MP containingBifidobacterium BB-12,Lactobacillus delbrueckii LBY-27,Lactobacillus acidophilus LA-Z,Streptococcus thermophilus STY-31 andLactobacillus paracasei LC-01 were used for supplementation. From day 0 post-supplementation (PS), rats in groups A –C received 1 × 109, 5  × 109 and 10  × 109 CFUs of MP daily and respectively. Groups D and E received no MP supplementation being the infected and uninfected controls respectively. On day 7PS, groups A –D were challenged with approximately 1 × 106Trypanosoma brucei intraperitoneally. On days 0, 7 and 16, PS, serum alanine and aspartate aminotransferases (ALT and AST) were determined spectrophotometrically, while parasitaemia, bodyweight and mortality were monitored. By day 7, PS groups B-D had similar ALT activities and AST-ALT ratios, while all groups had similar AST activities. On day 16, PS all infected groups (A –D) had similar and significantly (p <  0.05) lower AST activities and AST-ALT ratio compared to the uninfected control, while ALT activities were similar and significantly elevated in groups A-D. Logarithmic parasitaemia levels and AST-ALT ratio showed random moderate negative correlation (r = − 0.390;p = 0.059). No signific...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research