Co-impairment of autonomic and glucagon responses to insulin-induced hypoglycemia in dogs with naturally-occurring insulin-dependent diabetes mellitus.

CONCLUSIONS: 1) Impairment of glucagon responses in DMN dogs is not due to generalized impairment of alpha-cell function. 2) Loss of tonic inhibition of glucagon secretion by insulin is not sufficient to produce loss of the glucagon response; impairment of autonomic activation is also required. 3) In dogs with major beta-cell function loss, activation of the autonomic inputs is sufficient to mediate an intact glucagon response to IIH. PMID: 33044845 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33044845?dopt=Abstract

Source: American Journal of Physiology. Endocrinology and Metabolism - October 12, 2020 Category: Physiology Authors: Gilor C, Duesberg C, Elliott DA, Feldman EC, Mundinger TO, Taborsky GJ, Nelson RW, Havel PJ Tags: Am J Physiol Endocrinol Metab Source Type: research