Excisional treatment comparison for in situ endocervical adenocarcinoma (EXCISE): A phase 2 pilot randomized controlled trial to compare histopathological margin status, specimen size and fragmentation after loop electrosurgical excision procedure and cold knife cone biopsy.

CONCLUSIONS: LEEP was not associated with a greater likelihood of positive margins, specimen fragmentation or smaller excision compared to CKC when performed according to a standardized protocol. However, the study was not powered to establish non-inferiority of LEEP and a definitive phase 3 trial to compare margin status and rates of treatment failure after LEEP and CKC is warranted. PMID: 33032824 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33032824?dopt=Abstract

Source: Gynecologic Oncology - October 5, 2020 Category: Cancer & Oncology Authors: Cohen PA, Leung Y, Anderson L, van der Griend R, Chivers P, Bilic S, Bittinger S, Brand A, Bulsara MK, Codde J, Eva L, Farrell L, Harker D, Herbst U, Jeffares S, Loh D, McNally O, Mohan GR, Nicholson T, Powell A, Salfinger SG, Simcock B, Stewart C, Silver Tags: Gynecol Oncol Source Type: research