A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer.

This study results in an effective target cell-specific NLS therapeutic and a general approach to guide future NLS-based development initiatives. PMID: 33024794 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/33024794?dopt=Abstract

Source: Clinical Breast Cancer - October 9, 2020 Category: Cancer & Oncology Authors: Lacasse V, Beaudoin S, Jean S, Leyton JV Tags: Mol Ther Methods Clin Dev Source Type: research