Comparison of 123I-MIBG scintigraphy and phosphorylated α-synuclein skin deposits in synucleinopathies

Introduction: Cardiac [123I]metaiodobenzylguanidine scintigraphy (123I-MIBG) is considered a useful test in differentiating multiple system atrophy (MSA) and Lewy body disorders (LBD), including idiopathic Parkinson's disease (IPD), dementia with Lewy bodies (DLB) and pure autonomic failure (PAF). The detection of skin nerve phosphorylated- α-synuclein (p-α-syn) deposits could be an alternative marker in vivo. We sought to compare 123I-MIBG scintigraphy and skin biopsy findings in α-synucleinopathies.

Source: Parkinsonism and Related Disorders - October 7, 2020 Category: Neurology Authors: Maria Pia Giannoccaro, Vincenzo Donadio, Giulia Giannini, Grazia Devigili, Giovanni Rizzo, Alex Incensi, Ernesto Cason, Giovanna Calandra-Buonaura, Roberto Eleopra, Pietro Cortelli, Rocco Liguori Source Type: research