Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder

This study aimed to explore whether reduced cortical acetylcholinesterase activity in iRBD is linked to microglial activation in the substantia innominata (SI), the major source of cholinergic input to the cortex.

Source: Parkinsonism and Related Disorders - October 8, 2020 Category: Neurology Authors: Kristian St ær, Alex Iranzo, Morten G. Stokholm, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina B. Svendsen, Alicia Garrido, Dolores Vilas, Joan Santamaria, Arne Møller, Carles Gaig, David J. Brooks, Per Borghammer, Eduardo Tolosa, Nicola Pa Source Type: research