Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparities.

CONCLUSION: Our findings showed how sensitivity to high NRF1 transcriptional activity coupled with its target gene signatures contribute to racial differences in luminal A and TN breast cancer subtypes. This knowledge may be useful in personalized intervention to prevent and treat this clinically challenging problem.
PMID: 32705365 [PubMed - indexed for MEDLINE]

Source: Clinical Genitourinary Cancer - October 8, 2020 Category: Cancer & Oncology Authors: Ramos J, Yoo C, Felty Q, Gong Z, Liuzzi JP, Poppiti R, Thakur IS, Goel R, Vaid AK, Komotar RJ, Ehtesham NZ, Hasnain SE, Roy D Tags: J Cancer Res Clin Oncol Source Type: research