Quantitative evaluation of hepatic integrin α v β 3 expression by positron emission tomography imaging using 18 F-FPP-RGD 2 in rats with non-alcoholic steatohepatitis

ConclusionsWe have demonstrated that theVT (IDIF) of18F-FPP-RGD2, calculated using kinetic modelling, positively correlates with integrin αv and β3 protein in the liver of NASH rats. These findings suggest that hepaticVT (IDIF) provides a quantitative assessment of integrin αvβ3 protein in liver.

http://link.springer.com/10.1186/s13550-020-00704-3

Source: EJNMMI Research - October 6, 2020 Category: Radiology Source Type: research