GSE159104 Biomarker Discovery in Attention Deficit Hyperactivity Disorder: RNA sequencing of Whole Blood in Discordant Twin and Case-Controlled Cohorts

Contributors : Joel T Nigg ; Tim McCaffrey ; Georges St.Laurent ; Daniel Jones ; Dmitry Shtokalo ; Denis Antonets ; Yuri Vyatkin ; Eleanor BattisonSeries Type : Expression profiling by genome tiling arrayOrganism : Homo sapiensWe found RNA markers common to both the discordant twin study and case-controlled subjects further narrowed the putative targets, some of which had been previously associated with ADHD at the DNA level. The potential role of several differentially expressed genes, including ABCB5, RGS2, GAK, GIT1 and 3 members of the galactose metabolism pathway (GALE, GALT, GALK1) are substantiated by prior associations to ADHD and by established mechanistic connections to molecular pathways relevant to ADHD and behavioral control.

Source: GEO: Gene Expression Omnibus - October 7, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by genome tiling array Homo sapiens Source Type: research