Case series investigation on the Lewis system antibodies encountered during a routine screening in a tertiary care hospital-based blood center

Conclusion: Although antibodies to Lewis blood group antigens often react at lower temperatures and therefore remain clinically insignificant, some of them, on rare circumstances, may react at higher temperature of 37°C and may produce hemolytic episode or at least yield reduce survival of incompatible red cells in transfusion recipients. On safer side, the antigen-negative unit may be used in transfusion. The donors' registry with detailed phenotype profile may go a long way to provide blood for transfusion in emergency situations.

Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: AM Gayathri Debasish Gupta Source Type: research