Bristol part of new £ 4 million FDA study to advance understanding of severe coronavirus infection

Bristol is part of a major new international project to improve our understanding of severe coronavirus infection in humans. The study, funded by the US Food and Drug Administration (FDA), will analyse samples from humans and animals to create profiles of various coronaviruses, including SARS-CoV-2, which causes COVID-19. The results will help inform the development of new treatments and vaccines to tackle coronavirus infections.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Grants and Awards, Health, International, Research; Faculty of Life Sciences, Faculty of Life Sciences, School of Cellular and Molecular Medicine; Press Release Source Type: news

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In conclusion, ultra- and micro-structural changes presented in this study may provide useful information for SARS-CoV-2 studies in various fields.
Source: Veterinary Research - Category: Veterinary Research Source Type: research
In conclusion, the intramuscular EP-assisted DNA vaccine, COVID-eVax showed an excellent safety profile in SD rats under these experimental conditions and supports its further development for use in humans.PMID:34493107 | DOI:10.1177/01926233211042263
Source: Toxicologic Pathology - Category: Pathology Authors: Source Type: research
CONCLUSION: Our results provide new information on immunological cytokines and biological parameters related to the pathogenesis and immune response profile in the Syrian hamster model of SARS-CoV-2 infection.PMID:34408462 | PMC:PMC8366787 | DOI:10.2147/JIR.S323026
Source: Cell Research - Category: Cytology Authors: Source Type: research
In conclusion, prime-boost vaccination with 4 µg of vaccine candidate CV07050101 resulted in limited immune responses in four out of six non-human primates.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
ChAdOx1 nCoV-19/AZD1222 is an approved adenovirus-based vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently being deployed globally. Previous studies in rhesus macaques revealed that intramuscular vaccination with ChAdOx1 nCoV-19/AZD1222 provided protection against pneumonia but did not reduce shedding of SARS-CoV-2 from the upper respiratory tract. Here, we investigated whether intranasally administered ChAdOx1 nCoV-19 reduces detection of virus in nasal swabs after challenging vaccinated macaques and hamsters with SARS-CoV-2 carrying a D614G mutation in the spike protein. Viral loads in swa...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Multiple safe and effective vaccines that elicit immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are necessary to respond to the ongoing coronavirus disease 2019 (COVID-19) pandemic. Here, we developed a protein subunit vaccine composed of spike ectodomain protein (StriFK) plus a nitrogen bisphosphonate–modified zinc-aluminum hybrid adjuvant (FH002C). StriFK-FH002C generated substantially higher neutralizing antibody titers in mice, hamsters, and cynomolgus monkeys than those observed in plasma isolated from COVID-19 convalescent individuals. StriFK-FH002C also induced both TH1- ...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
From delivering nearly a quarter million COVID-19 vaccine doses to learning how puppies communicate, University of Arizona expertise in a variety of fields has made international headlines in 2021. Today University Communications2021.jpgBusiness and LawCampus NewsHealthScience and TechnologySocial Sciences and Education Media contact(s)Nick Prevenas Director, Media Relations, University Communicationsnprevenas@arizona.edu520-621-2194University of Arizona researchers are making waves in 2021 – and the year is only halfway over.Whether it's transforming the campus into a high-capacity COVID-19 vaccination site or c...
Source: The University of Arizona: Health - Category: Universities & Medical Training Authors: Source Type: research
Vaccine. 2021 Aug 5:S0264-410X(21)00964-6. doi: 10.1016/j.vaccine.2021.07.071. Online ahead of print.ABSTRACTModern vaccinology has experienced major conceptual and technological advances over the past 30 years. These include atomic-level structures driving immunogen design, new vaccine delivery methods, powerful adjuvants, and novel animal models. In addition, utilizing advanced assays to learn how the immune system senses a pathogen and orchestrates protective immunity has been critical in the design of effective vaccines and therapeutics. The National Institute of Allergy and Infectious Diseases of the National Institut...
Source: Vaccine - Category: Allergy & Immunology Authors: Source Type: research
Researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, engineered mini-antibodies, called nanobodies, against SARS-CoV-2. The team’s nanobodies are stable up to 95 degrees Celsius (203 F) and are cheaper a...
Source: Medgadget - Category: Medical Devices Authors: Tags: Medicine Nanomedicine Public Health Source Type: blogs
Hsueh Ooi Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus in humans, has expanded globally over the past year. COVID-19 remains an important subject of intensive research owing to its huge impact on economic and public health globally. Based on historical archives, the first coronavirus-related disease recorded was possibly animal-related, a case of feline infectious peritonitis described as early as 1912. Despite over a century of documented coronaviruses in animals, the global animal industry still suffers from outbreaks. Knowledge ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
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