Orthostatic hypotension as a core symptom in a Japanese family harboring SNCA duplication

a-Synuclein (SNCA) multiplication (PARK4) is responsible for Parkinson's disease (PD) with autosomal dominant inheritance. The occurrence of autonomic dysfunction is approximately 34% –38% in SNCA duplication carriers [1,2]. However, severe orthostatic hypotension as the most prominent symptom appears rare.

Source: Parkinsonism and Related Disorders - October 4, 2020 Category: Neurology Authors: Haitian Nan, Ryusuke Takaki, Tetsuhiro Maruyama, Yasuhisa Baba, Shinji Ohara, Kazumasa Shindo, Yoshihisa Takiyama Tags: Correspondence Source Type: research