Incidental findings of temporomandibular joint osteoarthritis and its variability based on age and sex.

Conclusion: Female patients had a higher prevalence and severity of TMJ-OA than male patients. The prevalence and severity of TMJ-OA increased with age, with peaks in the fifth and seventh decades of life. PMID: 33005582 [PubMed]
Source: Imaging Science in Dentistry - Category: Dentistry Tags: Imaging Sci Dent Source Type: research

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AbstractOsteoarthritis (OA) is a debilitating disease. A number of treatments like conservative approach, minimally invasive procedures and surgical therapy have proved to be beneficial. However, there is no consensus regarding the use of a single modality of treatment. Our current study evaluates the role of intra articular injection iPRF along with arthrocentesis for the management of temporomandibular joint osteoarthritis (TMJ-OA). A total of 130 patients were selected and divided into two groups, Group A (arthrocentesis only group) and Group B (arthrocentesis +i-PRF). Patients were evaluated for pain scores and maximal...
Source: Oral Surgery - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research
In this study, we investigate harnessing fibrocartilage stem cell (FCSC) capacities by regulating tumor necrosis factor α (TNF-α) signaling for cartilage repair in temporomandibular joint osteoarthritis (TMJOA). Stem cell specifics for FCSCs were characterized in the presence of TNF-α. Etanercept as a TNF-α inhibitor and BAY 11-7082 as an Nf-κB inhibitor were used to study TNF-α regulation of FCSCs. Lineage tracing was performed in Gli1-CreERT+;Tmfl/fl mice when etanercept (1 mg/kg, every 3 d) or isometric vehicle was subcutaneously injected to trace specific changes in FCSCs. Surgically...
Source: Cell Research - Category: Cytology Authors: Source Type: research
To observe and analyze the interaction between excessive mechanical stress (MS) and decreased sex hormones on Temporomandibular Joint Osteoarthritis (TMJ-OA), and to discover TMJ-OA disease susceptibility genes by molecular biological analysis to elucidate part of the mechanism of TMJ-OA onset.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
CONCLUSIONS: While the HCA increased in the presence of TMJ OA, no relationship was found between HCA and three different condylar positions.PMID:34355786 | DOI:10.5603/FM.a2021.0075
Source: Folia Morphologica - Category: Anatomy Authors: Source Type: research
To assess the level of evidence for genetic, biologic, and functional predictive and predisposing factors for end-stage temporomandibular joint arthritis within published literature.
Source: The British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Review Source Type: research
Biomed Res Int. 2021 Jul 9;2021:9978651. doi: 10.1155/2021/9978651. eCollection 2021.ABSTRACTTemporomandibular joint osteoarthritis (TMJOA) is characterized by chronic inflammatory degradation of mandibular condylar cartilage (MCC). Studies have found a positive correlation between inflammation and cyclooxygenase- (COX-) 2 in OA pathology. NF-κB is a crucial transcription factor of inflammatory and immune responses in the cause of TMJOA pathology. Resveratrol (RES) plays a critical role in antioxidation and anti-inflammation. But, studies on the effects of RES on TMJOA are very limited. So, the purpose of this study ...
Source: Biomed Res - Category: Research Authors: Source Type: research
In terms of diagnostic and therapeutic management, clinicians should adequately address the frequent aspects of temporomandibular joint (TMJ) osteoarthritis (OA) associated with disk displacement. Condylar ero...
Source: BMC Oral Health - Category: Dentistry Authors: Tags: Research Source Type: research
In conclusion, in our prospective community-based study, aging-related biomarkers were associated with measures of subclinical atherosclerosis cross-sectionally and with all-cause mortality prospectively, supporting the concept that these biomarkers may reflect the aging process in community-dwelling adults. The Role of Aging Macrophages in Skin Inflammation https://www.fightaging.org/archives/2021/06/the-role-of-aging-macrophages-in-skin-inflammation/ The immune system is complex and ages in complex ways, pressed by the lifetime burden of infection and rising levels of molecular damage that trigger many...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Senescent cell accumulation appears to be a major player in the pathology of most of the joint-related issues that occur in older individuals. Senescent cells secrete signals that provoke a state of chronic inflammation, alter nearby cell behavior, and disrupt tissue structure and maintenance. Clearance of these cells reverses numerous age-related conditions and measures of aging in mice. Hence the advent of senolytic therapies that selectively destroy senescent cells is a much anticipated development in medicine. Indeed, the first such therapies are pre-existing drugs, such as the dasatinib and quercetin combination, are ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
To explore the suppressing impact of low phosphorus intake on osteoarthritic temporomandibular joint and the possible mechanisms of nuclear acid injury in the insulted chondrocytes.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
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