Recognition of G-quadruplex topology through hybrid binding with implications in cancer theranostics

Conclusion: Intervention of GQ mediated lethality by TGP18 has translated into anti-cancer activity in both in vitro 3D spheroid culture and in vivo xenograft models of lung and breast cancer with superior efficacy for the former. In vivo therapeutic efficacy supplemented with tumor 3D spheroid and tissue imaging potential define the role of TGP18 in GQ-targeted cancer theranostics.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yelisetty Venkata Suseela, Pardhasaradhi Satha, N. Arul Murugan, Thimmaiah Govindaraju Tags: Research Paper Source Type: research