Cellular Immunotherapies in Pre-Clinical Large Animal Models of Transplantation

Acute and chronic rejection as well as the deleterious effects associated with long-term immunosuppression are leading causes of allograft failure following transplantation. The use of “regulatory” cell therapy to prevent graft-versus-host disease (GVHD) and improve solid organ transplant outcomes has been a long-standing endeavor. While numerous murine studies have documented the effects of various “regulatory” cell types in modulating the alloimmune response in favor of graft tolerance, translation to pre-clinical and clinical models has been met with mixed results.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research