Nrf2 Appears to Be Downregulated in Steatotic Compared with Lean Liver Allografts - A Potential Role for Targeted Therapies

Hepatic steatosis (HS) is a key factor predicting postoperative allograft function and determining overall discard in liver transplantation (LT). The potential of normothermic machine perfusion (NMP) as an adjunct to LT has been a focus of recent scrutiny due to its ability to attenuate ischemia reperfusion injuries (IRI) and maintain graft functionality. The nuclear-factor-erythroid 2-related-factor-2 (Nrf2) axis may be an important IRI mediator in HS. We aimed to characterize and compare Nrf2 expression profiles between lean and steatotic tissue undergoing NMP.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Transplantation and tissue engineering Source Type: research