Zwitterionic Polydopamine Engineered Interface for In Vivo Sensing with High Biocompatibility.

Zwitterionic Polydopamine Engineered Interface for In Vivo Sensing with High Biocompatibility. Angew Chem Int Ed Engl. 2020 Sep 16;: Authors: Zhang M, Feng T, Ji W, Zhang Y, Wu F, Tang Q, Wei H, Mao L Abstract Electrochemical sensing performance is often compromised by electrode biofouling (e.g., protein nonspecific binding) in complex biological fluids; however, the design and construction of a robust biointerface with superior antifouling ability and high tolerance of free radicals and excellent electrochemical performance remains a great challenge. Herein, inspired by nature, we demonstrate a robust polydopamine-engineered biointerfacing, to tailing zwitterionic molecules (i.e., sulfobetaine methacrylate, SBMA) through Michael Addition. The SBMA-PDA biointerface can resist nonspecific binding of proteins in complex biological fluids while enhancing interfacial electron transfer and electrochemical stability of the electrode. In addition, this sensing interface can be integrated with tissue-implantable microelectrode for in vivo analysis, preserving more than 92.0% of the initial sensitivity after 2 h of implantation in brain tissue and showing low acute neuroinflammatory responses. Moreover, this implantable microsensor demonstrates good stability both in normal and in Parkinson's disease (PD) rat brain tissue. This PDA-engineered zwitterionic biointerface is believed to be used to construct universal interface enabling wide analy...
Source: Angewandte Chemie - Category: Chemistry Authors: Tags: Angew Chem Int Ed Engl Source Type: research