Circulation of Nipah virus at the human-Flying fox interface in Cambodia

Background: Nipah virus (NiV) is an emerging pathogen that, unlike other priority pathogens identified by WHO, is endemic to Southeast Asia. It is transmitted through exposure to saliva, urine or excrement from Pteropus fruit bats or direct contact with intermediate animal hosts or human-to-human transmission. However, little is known about the circulation of NiV and its epidemiology in Cambodia.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0529 Source Type: research

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Conclusions. The two peptides TVYHCSAVY and FLIDRINWI have showed a very strong binding affinity to MHC class I and MHC class II alleles. Furthermore, considering the conservancy, the affinity, and the population coverage, the peptide FLIDRINWIT is highly suitable to be utilized to formulate a new vaccine against glycoprotein G of Nipah henipavirus. An in vivo study for the proposed peptides is also highly recommended. PMID: 32377531 [PubMed - in process]
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
unjie Xu Wei Chen The genus Henipavirus (HNVs) includes two fatal viruses, namely Nipah virus (NiV) and Hendra virus (HeV). Since 1994, NiV and HeV have been endemic to the Asia–Pacific region and responsible for more than 600 cases of infections. Two emerging HNVs, Ghana virus (GhV) and Mojiang virus (MojV), are speculated to be associated with unrecognized human diseases in Africa and China, respectively. Despite many efforts to develop vaccines against henipaviral diseases, there is presently no licensed human vaccine. As HNVs are highly pathogenic and diverse, it is necessary to develop universal vaccin...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
This article describes elements of design of such unit (e.g., space, infection control, waste disposal, safety of healthcare workers, partners to be involved in design and plan) which can be adapted to the context of either a new construction or makeshift construction on top of an existing structure. In view of a potential epidemic of COVID-19, specific requirements to handle it are also given. PMID: 32202258 [PubMed - as supplied by publisher]
Source: Indian J Med Res - Category: Research Authors: Tags: Indian J Med Res Source Type: research
In this study, we generated two recombinant RABVs, rERAG333E/NiVG and rERAG333E/NiVF, expressing the NiV Malaysian strain attachment glycoprotein (NiV-G) or fusion glycoprotein (NiV-F) gene based on the rERAG333E vector platform. Both rERAG333E/NiVG and rERAG333E/NiVF displayed growth properties similar to those of rERAG333E and caused marked syncytia formation after co-infection in BSR cell culture. Adult and suckling mice intracerebrally inoculated with the recombinant RABVs showed NiV-G and NiV-F expression did not increase the virulence of rERAG333E. Oral vaccination with rERAG333E/NiVG either singularly or combined wi...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Ten people in the South Indian state of Kerala have died after being infected by the Nipah virus, an emerging disease thought to be spread by fruit bats and other animals. Here’s what you should know about the outbreak. What is the Nipah virus? The Nipah virus is a highly contagious and deadly virus that was first identified in 1999 when pig farmers in Malaysia and Singapore became very sick. During that outbreak, nearly 300 people were infected, and more than 100 people died. To stop the outbreak, authorities had to euthanize over one million pigs. Since then, the virus has been identified in outbreaks in Bangladesh...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime public health Source Type: news
Publication date: Available online 31 May 2016 Source:Asian Pacific Journal of Tropical Medicine Author(s): Silvia Angeletti, Alessandra Lo Presti, Eleonora Cella, Massimo Ciccozzi Nipah virus (NiV) is a member of the genus Henipavirus of the family Paramyxoviridae, characterized by high pathogenicity and endemic in South Asia. It is classified as a Biosafety Level-4 (BSL-4) agent. The case-fatality varies from 40%-70% depending on the severity of the disease and on the availability of adequate healthcare facilities. At present no antiviral drugs are available for NiV disease and the treatment is just supportive. Phy...
Source: Asian Pacific Journal of Tropical Medicine - Category: Tropical Medicine Source Type: research
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Source: Journal of Medical Virology - Category: Virology Authors: Tags: Research Article Source Type: research
Summary Many wild swine populations in different parts of the World have experienced an unprecedented demographic explosion that may result in increased exposure of humans to wild swine zoonotic pathogens. Interactions between humans and wild swine leading to pathogen transmission could come from different ways, being hunters and game professionals the most exposed to acquiring infections from wild swine. However, increasing human settlements in semi‐natural areas, outdoor activities, socio‐economic changes and food habits may increase the rate of exposure to wild swine zoonotic pathogens and to potentially emerging pa...
Source: Transboundary and Emerging Diseases - Category: Veterinary Research Authors: Tags: Review Article Source Type: research
by Peter J. Hotez, Maria Elena Bottazzi, Ulrich Strych, Li-Yen Chang, Yvonne A. L. Lim, Maureen M. Goodenow, Sazaly AbuBakar The ten member states of the Association of Southeast Asian Nations (ASEAN) constitute an economic powerhouse, yet these countries also harbor a mostly hidden burden of poverty and neglected tropical diseases (NTDs). Almost 200 million people live in extreme poverty in ASEAN countries, mostly in the low or lower middle-income countries of Indonesia, the Philippines, Myanmar, Viet Nam, and Cambodia, and many of them are affected by at least one NTD. However, NTDs are prevalent even among upper middle...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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