Characterizing dynamics of serum creatinine and creatinine clearance in extremely low birth weight neonates during the first 6 weeks of life

ConclusionsWe report the first mathematical model able to characterize Scr and CLcr in ELBW neonates during the first 6  weeks of life in a quantitative manner as a function of GA, MOD, and ibuprofen treatment. This model allows the derivation of GA-adjusted reference ranges for ELBW neonates and provides a rationale for normative Scr concentrations, and as such will help clinicians to further optimize monitoring an d treatment decisions in this vulnerable patient population.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research