ABCF1 Regulates dsDNA-induced Immune Responses in Human Airway Epithelial Cells

Conclusion: ABCF1 is a candidate cytosolic nucleic acid sensor and modulator of TLR signaling that is expressed at gene and protein levels in human airway epithelial cells. The precise level where ABCF1 protein functions to modulate immune responses to pathogens remains to be determined but is anticipated to involve IRF-3 and CXCL10 production.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research