This Month in AJP

The combined role of p53 and Kras in castration-resistant prostate cancer (CRPC) is unclear. To understand this role, Chung et al (Am J Pathol, AJPA-D-20-00076) generated a metastatic prostate cancer mouse model. The tumor suppressor gene Trp53 was deleted and the proto-oncogene Kras activated. These mice exhibited early onset metastatic progression of prostate cancer, which was androgen receptor negative. Gene encoding Pi3k γ (Pik3cg) was highly expressed in tumors. Chemically blocking PI3Kγ prevented tumor cell growth in vitro, reverted epithelial-mesenchymal transition, and decreased tumor metastasis in vivo.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: This Month in AJP Source Type: research