Emicizumab Augments Thrombus Formation in Whole Blood from Patients with Hemophilia A under High Shear Flow Conditions.

CONCLUSION:  Emicizumab enhanced thrombin generation at local sites and improved defective hemostasis in whole blood from PwHAs under high shear conditions. Simple concomitant use of BPAs with emicizumab did not mediate excessive thrombus formation and remains an option for hemostatic management of emicizumab-treated PwHAs with inhibitors.
PMID: 32906155 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - September 8, 2020 Category: Hematology Authors: Yaoi H, Shida Y, Kitazawa T, Shima M, Nogami K Tags: Thromb Haemost Source Type: research