YY1 deficiency in β-cells leads to mitochondrial dysfunction and diabetes in mice

The transcription factor YY1 is an important regulator for metabolic homeostasis. Activating mutations in YY1 lead to tumorigenesis of pancreatic β-cells, however, the physiological functions of YY1 in β-cells are still unknown. Here, we investigated the effects of YY1 ablation on insulin secretion and glucose metabolism.

Source: Metabolism - Clinical and Experimental - September 7, 2020 Category: Biomedical Science Authors: Dalong Song, Qi Yang, Xiuli Jiang, Aijing Shan, Jingminjie Nan, Ying Lei, He Ji, Wei Di, Tianxiao Yang, Tiange Wang, Weiqing Wang, Guang Ning, Yanan Cao Source Type: research