A mutation in POLR3E impairs antiviral immune response and RNA polymerase III [Biochemistry]

RNA polymerase (Pol) III has a noncanonical role of viral DNA sensing in the innate immune system. This polymerase transcribes viral genomes to produce RNAs that lead to induction of type I interferons (IFNs). However, the genetic and functional links of Pol III to innate immunity in humans remain largely...

Source: Proceedings of the National Academy of Sciences - September 7, 2020 Category: Science Authors: Aravind Ramanathan, Michael Weintraub, Natalie Orlovetskie, Raphael Serruya, Dhivakar Mani, Orly Marcu, Polina Stepensky, Yiska Weisblum, Esther Djian, Avraham Shaag, Shoshana Revel-Vilk, Iris Fried, Moshe Kotler, Alex Rouvinski, Dana Wolf, Orly Elpeleg, Tags: Biological Sciences Source Type: research