Mechanisms of early Recurrence in Intracranial Atherosclerotic Disease (MyRIAD): Rationale and design

Intracranial atherosclerotic disease (ICAD) is the most common cause of ischemic stroke with the highest rate of recurrence, despite aggressive medical management. Diverse mechanisms may be responsible for ICAD-related cerebral ischemia, with potential therapeutic implications. Here we present the rationale, design and methods of the Mechanisms of Early Recurrence in Intracranial Atherosclerotic Disease (MyRIAD) study. The aim of MyRIAD is to determine the mechanisms of stroke in ICAD through physiologic imaging biomarkers that evaluate impaired antegrade flow, poor distal perfusion, abnormal vasoreactivity, artery to artery embolism, and their interaction.

Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: David S Liebeskind, Shyam Prabhakaran, Nizam Azhar, Edward Feldmann, Iszet Campo-Bustillo, Rajbeer Sangha, Sebastian Koch, Tatjana Rundek, Lauren Ostergren, Marc I. Chimowitz, Jose G. Romano, MyRIAD Investigators Source Type: research