Associations of early-year exposure to famine with abdominal fat accumulation are independent of family history of diabetes and physical activity.

Associations of early-year exposure to famine with abdominal fat accumulation are independent of family history of diabetes and physical activity. Br J Nutr. 2020 Sep 02;:1-20 Authors: Hu X, Wen J, Yu W, Yang L, Pan W, Xu K, Chen X, Li Q, Chen G, Gu X Abstract The present study aimed to investigate the association of early-year exposure to famine with abdominal fat accumulation and function, and further evaluate the influence of first-degree family history of diabetes and physical activity on this association. The present work analyzed parts of the REACTION study. A total of 3033 women were enrolled. Central obesity was defined as waist circumferences (W) ≥ 85 cm. Chinese visceral adiposity index (CVAI) was used to evaluate visceral adipose distribution and function. Partial correlation analysis showed body mass index (BMI), W, glycated hemoglobin A1c, and CVAI were associated with early-year exposure of famine (both P < 0.05). Logistic regression showed that the risks of overall overweight/obesity and central obesity in fetal, early-childhood, mid-childhood, and late-childhood exposed subgroups were increased significantly (all P < 0.05). Compared with non-exposed group, the BMI, W, and CVAI of fetal, early- to late-childhood exposed subgroups were significantly increased both in those with or without first-degree family history of diabetes, and in those classified as physically active or inactive, respectively (all P < 0...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research