R93P Substitution in the PmrB HAMP Domain Contributes to Colistin Heteroresistance in Escherichia coli Isolates from Swine.

In conclusion, point mutations in PmrB and/or PhoQ were primarily associated with CHR. The R93P substitution resulted in the establishment of stable resistant subpopulations in E. coli showing CHR.
PMID: 32868331 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - August 30, 2020 Category: Microbiology Authors: Kuang Q, He D, Sun H, Hu H, Li F, Li W, Hu G, Wu H, Yuan L Tags: Antimicrob Agents Chemother Source Type: research