T1 and T2 MR fingerprinting measurements of prostate cancer and prostatitis correlate with deep learning –derived estimates of epithelium, lumen, and stromal composition on corresponding whole mount histopathology

ConclusionSignificant associations between MRF (T1 in the TZ and T2 in the PZ) and tissue compartments on corresponding histopathology were observed.Key Points•Mean T2 MRF measurements and ADC within cancerous regions of interest dropped with increasing ISUP prognostic groups (IPG).•Mean T1 and T2 MRF measurements were significantly different (p  <  0.001) across IPGs, prostatitis, and normal peripheral zone (NPZ).•T2 MRF showed stronger correlations in the peripheral zone, while T1 MRF showed stronger correlations in the transition zone with histopathology for prostate cancer.
Source: European Radiology - Category: Radiology Source Type: research