Promising and Upcoming Treatments in Myositis

AbstractPurpose of ReviewTo highlight new and emerging treatment targets in myositis.Recent FindingsThe landscape of novel therapeutics in myositis has vastly changed in the past 5 years. This is largely due to a greater understanding of the pathogenesis of myositis and validation of more robust outcome measures that standardize the ability to assess treatment response. Clinical trials in dermatomyositis are leading the way with ongoing multicenter, international phase 3 cli nical trials. Proof-of-concept studies targeting the JAK/STAT pathway have also showed early promise in treating refractory dermatomyositis in adults and children.SummaryThis review highlights that the future armamentarium of therapeutic drugs will likely be larger and more selective in treating different subgroups of myositis.

http://link.springer.com/10.1007/s11926-020-00943-2

Source: Current Rheumatology Reports - August 25, 2020 Category: Rheumatology Source Type: research