Performance of PCR/Electrospray Ionization-Mass Spectrometry on Whole Blood for Detection of Bloodstream Microorganisms in Patients with Suspected Sepsis [Bacteriology]

In conclusion, PCR/ESI-MS showed excellent performance on contrived samples. On clinical samples, it showed high specificities, moderately high sensitivities for Gram-negative bacteria and Candida species, and elevated positivity rates during antimicrobial treatment. These promising results encourage further development of molecular diagnostics to be used with whole blood for detection of bloodstream microorganisms in sepsis.

Source: Journal of Clinical Microbiology - August 23, 2020 Category: Microbiology Authors: Stralin, K., Rothman, R. E., Özenci, V., Barkataki, K., Brealey, D., Dhiman, N., Poling, L., Kurz, M. C., Limaye, A. P., LoVecchio, F., Lowery, K., Miller, L. G., Moran, G. J., Overcash, J. S., Parekh, A., Peacock, W. F., Rivers, E. P., Sims, M., Tags: Bacteriology Source Type: research