G-CSF Attenuates Neuroinflammation and Stabilizes the Blood-Brain Barrier via the PI3K/Akt/GSK-3β Signaling Pathway Following Neonatal Hypoxia-Ischemia in Rats.

CONCLUSIONS:: We demonstrate G-CSF plays a pivotal role in attenuating neuroinflammation and BBB disruption following HI by inactivating GSK-3β through the PI3K/Akt pathway.
PMID: 25585014 [PubMed - as supplied by publisher]

Source: Experimental Neurology - January 10, 2015 Category: Neurology Authors: Li L, McBride DW, Doycheva D, Dixon BJ, Krafft PR, Zhang JH, Tang J Tags: Exp Neurol Source Type: research