Heterogeneity of Dengue Illness in Community-Based Prospective Study, Iquitos, Peru.

Heterogeneity of Dengue Illness in Community-Based Prospective Study, Iquitos, Peru. Emerg Infect Dis. 2020 Sep;26(9):2077-2086 Authors: Elson WH, Reiner RC, Siles C, Bazan I, Vilcarromero S, Riley-Powell AR, Kawiecki AB, Astete H, Hontz RD, Barker CM, Vazquez-Prokopec GM, Morrison AC, Scott TW, Elder JP, Rothman AL, Paz-Soldan VA Abstract Measuring heterogeneity of dengue illness is necessary to define suitable endpoints in dengue vaccine and therapeutic trials and will help clarify behavioral responses to illness. To quantify heterogeneity in dengue illness, including milder cases, we developed the Dengue Illness Perceptions Response (IPR) survey, which captured detailed symptom data, including intensity, duration, and character, and change in routine activities caused by illness. During 2016-2019, we collected IPR data daily during the acute phase of illness for 79 persons with a positive reverse transcription PCR result for dengue virus RNA. Most participants had mild ambulatory disease. However, we measured substantial heterogeneity in illness experience, symptom duration, and maximum reported intensity of individual symptoms. Symptom intensity was a more valuable predicter of major activity change during dengue illness than symptom presence or absence alone. These data suggest that the IPR measures clinically useful heterogeneity in dengue illness experience and its relation to altered human behavior. PMID: 32818402 [Pu...
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research