Obesity & genetic predisposition with COVID-19

We aimed to examine the associations of obesity-related traits (body mass index [BMI], central obesity) and their genetic predisposition with the risk of developing severe COVID-19 in a population-based data.Research Design and Methods.We analyzed data from 489,769 adults enrolled in the UK Biobank —a population-based cohort study. The exposures of interest are BMI categories and central obesity (e.g., larger waist circumference). Using genome-wide genotyping data, we also computed polygenic risk scores (PRSs) that represent an individual's overall genetic risk for each obesity trait.

Source: Metabolism - Clinical and Experimental - August 20, 2020 Category: Biomedical Science Authors: Zhaozhong Zhu, Kohei Hasegawa, Baoshan Ma, Michimasa Fujiogi, Carlos A. Camargo, Liming Liang Source Type: research