Simultaneous activation of the small conductance calcium-activated potassium current by acetylcholine and inhibition of sodium current by ajmaline cause J-wave syndrome in Langendorff-perfused rabbit ventricles

Concomitant apamin-sensitive small conductance calcium-activated potassium current (IKAS) activation and sodium current inhibition induce J-wave syndrome (JWS) in rabbit hearts. Sudden death in JWS occurs predominantly in men at night when parasympathetic tone is strong.

Source: Heart Rhythm - August 2, 2020 Category: Cardiology Authors: Yu-Dong Fei, Mu Chen, Shuai Guo, Akira Ueoka, Zhenhui Chen, Michael Rubart-von der Lohe, Thomas H. Everett, Zhilin Qu, James N. Weiss, Peng-Sheng Chen Source Type: research