Intention-to-treat analysis in precision oncology: A cautious interpretation

Randomised clinical trials (RCTs) are the best available study designs to confirm the effectiveness of a new intervention. The process of randomisation produces two prognostically equal groups which are similar in all aspects except that one group receives the new intervention whereas the other does not. However, these two groups may not remain similar in due course after randomisation if the participants leave their assigned groups because of varied reasons – high cost, more side effects, inconvenience, alternative options, etc.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Letter to the Editor Source Type: research