All-polysaccharide, self-healing injectable hydrogels based on chitosan and oxidized hydroxypropyl polysaccharides.

All-polysaccharide, self-healing injectable hydrogels based on chitosan and oxidized hydroxypropyl polysaccharides. Biomacromolecules. 2020 Aug 18;: Authors: Chen J, Nichols B, Norris A, Frazier CE, Edgar KJ Abstract Polysaccharide-based hydrogels are attractive materials for biomedical applications for reasons that include their polyfunctionality, generally benign nature, and biodegradability. However, use of polysaccharide-based hydrogels may be limited by toxicity arising from small molecule crosslinkers, or may involve undesired chemical modification. Here, we report a green, simple, efficient strategy for preparation of polysaccharide-based, in situ forming hydrogels. The Edgar group reports in the accompanying manuscript that chemoselective oxidation of oligo(hydroxypropyl)-substituted polysaccharides introduces ketone groups at the termini of the oligo(hydroxypropyl) chains. Amine containing moieties can condense with ketones to form imines. The imine linkage is dynamic in the presence of water, providing the potential for self-healing, injectability, and pH responsiveness. In this work, we designed and prepared two different types of hydrogels, oxidized hydroxypropyl cellulose/chitosan (OX-HPC-Chitosan) and oxidized hydroxypropyl dextran/chitosan (OX-HPD-Chitosan), each crosslinked by imine bonds. The mechanical properties of these hydrogels were characterized by rheometry, revealing that hydrogel storage modulus could be tun...
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research