Spotlight on fowl adenovirus (FAdV) in chickens and beyond - an unresolved host-pathogen interplay.

Spotlight on fowl adenovirus (FAdV) in chickens and beyond - an unresolved host-pathogen interplay. Avian Pathol. 2020 Aug 14;:1-13 Authors: Schachner A, Grafl B, Hess M Abstract Fowl adenovirus (FAdV) infections in chickens underwent substantial changes in recent decades, driven by host and pathogen factors. Based on the pathogenesis of inclusion body hepatitis (IBH) and hepatitis-hydropericardium syndrome (HHS) modern broilers are much more inclined to have difficulties keeping the metabolic homeostasis, whereas adenoviral gizzard erosion (AGE) is noticed equally in broilers and egg layers. Defining the importance of certain serotypes for specific FAdV diseases is a major achievement of recent years but the isolation of viruses from clinically healthy birds remains unexplained, as virulence factors are hardly known and continue to be a "black box". Together with further studies on pathogenesis of FAdV induced diseases such knowledge on virulence factors would help to improve protection strategies, which presently concentrate on autogenous vaccines of breeders to prevent vertical transmission. PMID: 32795192 [PubMed - as supplied by publisher]
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research