25-Hydroxyvitamin D and Advanced Glycation Endproducts in Healthy and Hypertensive Subjects: Are There Interactions?

Advanced glycation endproducts (AGEs) accumulate during aging. Skin is the single organ of vitamin D synthesis, induced by ultraviolet B light. Accumulation of AGEs in the skin could interfere with synthesis of the vitamin, whereas the microinflammation and oxidative stress (associated with hypovitaminosis D) could amplify both the toxic effects of AGEs and their production. Clinical data on potential interactions between vitamin D3 deficiency and AGE accumulation are sparse. Here we investigated potential associations between levels of circulating vitamin D3 and those of AGEs in blood and skin with regard to markers of inflammation and oxidative stress in nondiabetic subjects.
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: ICURT PROCEEDINGS Source Type: research