Pharmacological and genetic inhibition of TRPC6-induced gene transcription.

In this study it is shown that both compounds, in addition to inhibiting TRPC6-induced signaling, completely abolished pregnenolone sulfate-mediated signaling via TRPM3 channels. Thus, SAR 7334 and larixyl acetate are not TRPC6-specific inhibitors. PMID: 32758574 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32758574?dopt=Abstract

Source: European Journal of Pharmacology - August 2, 2020 Category: Drugs & Pharmacology Authors: Scheuble J, Rössler OG, Ulrich M, Thiel G Tags: Eur J Pharmacol Source Type: research